Treating Major Depressive Disorder with Duloxetine

Duloxetine is a medicine to treat major depressive disorder. It helps to cure anxiety disorder, nerve pain in case of diabetes patients. It even gives relieve in fibro-myalgia. Duloxetine belongs to the class of SNRI drugs for treating depression and other disorders. It is helpful in arthritis and chronic back pain.


Lilly researchers discover Duloxetine. Four persons including the co-discoverer of fluoxetine were inventors on the patent application. They filled it in 1986 and was granted in 1990. In 2001, Lilly filled a new drug application for this drug with the USA FDA. It got approval for various disease – see the step by step below;

YEAR                                                 APPROVAL

Sep 7, 2004                              For the treatment of generalized anxiety disorder

Feb 26, 2007                            For the treatment of nerve pain related to diabetes

Nov 3, 2009                             Treatment for maintenance of anxiety disorder

Nov 5, 2010                              For the treatment of chronic muscles and skeleton pain

As you can see it got  approval for various disease slowly over the years.


It is available in the form of tablets. The strength are 20 mg, 30 mg, 40 mg, and 60 mg. The Maximum dose is 120 mg per day.  Dosage depends upon the disease and its intensity. This varies from person to person. Increase in dose is step by step as required by patient.

Don’t chew, crush or open tablet. Swallow it as whole with water or other liquid. Take it with or without food.



It can show withdrawal effects such as;

Major Side Effects

In rare cases it can lead to major side effects .It is necessary to look for doctors if any of the following symptoms occur.



Generic drugs have same active ingredient as in brand drugs. It is a lower version of a brand drug. They vary in terms of packaging and pricing. The cost is 30- 80% low than brand drugs. Cost of 60 mg tablet of generic duloxetine cost $1.11. Cost of brand Cymbalta is $17 to $30 USD . There is a great difference in cost yet the generic and brand have the exact same effect on health – just not in the wallet.

This content was originally published here.



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